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A, Dose response to sc injected B12-PYY3–36 on cumulative food intake in five rats, demonstrating only 10 nmol/kg, produced a rapid and prolonged FI reduction. B, Pharmacokinetic profile of B12-PYY3–36 (n = 4) and PYY3–36 (n = 3) sc injected at 10 nmol/kg. *, P < .05; **, P < .01 compared with PYY3–36.
