Figure 4.

Twenty-four-hour food intake patterns averaged over 5 days' duration. Food intake under baseline conditions in 22 rats (A) in comparison with after treatments receiving pulses of B₁₂-PYY_3–36 conjugate (n = 9), PYY_3–36 (n = 8), or the null conjugate B₁₂-PYY_C36 (n = 6). Representative food intake patterns of single animals receiving drugs PYY_3–36 (B), B₁₂-PYY_3–36 (C), or B₁₂-PYY_C36 (D), respectively, are shown. The averaged food intake for all animals per group over 5 days are shown for rats treated by B₁₂-PYY_3–36 conjugate (E) vs PYY_3–36 (F).