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EE in WT and KO male mice during chronic administration of ghrelin. A, Effect on EE of chronic administration of ghrelin (peripheral administration of 50 μg, sc, twice a day; D–F: icv infusion of 2.5 nmol/d) or vehicle for 1 week in WT and KO male mice. B, One-week EE relative to BW. Analysis of covariance revealed a significant effect of BW (F = 10.71, P < .01), but not treatment of genotype, on EE. Data presented as mean ± SEM, n = 6 per group.
