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. 2015 Mar 9;156(5):1714–1723. doi: 10.1210/en.2014-1781

Figure 7.

Figure 7.

Enhanced ghrelin-induced adiposity in female KO mice. Effect on food intake (A), BW gain (B), and fat mass gain of chronic administration of ghrelin (50 μg, sc, twice a d) for 10 days in female KO mice. A, In contrast to WT mice, ghrelin treatment led to a slight but significant increase in food intake after 10 days of treatment (P < .01, treatment × genotype by two-way ANOVA; *, P < .05 KO ghre vs KO veh; Bonferroni post hoc test). B, At the end of the 10-day period of treatment with ghrelin, there was a statistically significant interaction (P < .05, two-way ANOVA) between treatment and genotype on BW change. Only KO mice showed a significant increase in BW (P < .001, KO ghre vs KO veh; two-way ANOVA, Bonferroni post hoc test). C, Consistent with the effect on BW, ghrelin treatment significantly increased fat mass in KO mice (P < .001, two-way ANOVA, Bonferroni post hoc test). Data presented as mean ± SEM, n = 5–6 mice per group.