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. 2015 Mar 9;156(5):1648–1658. doi: 10.1210/en.2014-1892

Figure 1.

Figure 1.

Muscle-specific inactivation of CGI-58 causes cardiac and soleus steatosis. A, Muscle-specific deletion of CGI-58. Western blotting was performed using homogenates of tissues from adult mCgi58-KO (KO) mice and their littermates (Con). B, The gross appearance of hearts at necropsy showing the normal heart from control mice and the fatty and enlarged heart from mCgi58-KO mice. C, Increases in percentages of heart-to-body weight ratios in mCgi58-KO mice (n = 4–6) (**, P < .0001). D and E, H&E and Oil red-O staining showing LD and neutral lipid deposition in the LV (D) and soleus (E) muscles of mCgi58-KO mice. F, Representative electron micrographs of heart taken at ×2900. G, Representative electron micrographs of heart taken at ×9300, showing cardiac mitochondria and LDs.