Fig. 2.
Effects of calcium inhibitors on flow-induced changes in fluid (Jv; A), sodium (JNa; B), bicarbonate (JHCO3; C), and chloride (JCl; D) absorption in proximal tubules. Jv, JNa, JHCO3, and JCl absorption were measured at low and high perfusion rates under the conditions of absence (control group) and presence of cell-permeant Ca2+ chelator BAPTA-AM (10−7 M), inositol 1,4,5-trisphosphate (IP3) receptor antagonist 2-aminoethoxydiphenyl borate (2-APB; 10−5 M), or Ca-ATPase inhibitor thapsigargin (10−7 M) in the luminal perfusate. *P < 0.05, compared with low flow rates in the same group. †P < 0.05, compared with the control at the similar flow rate.