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. 2015 Feb 19;308(8):G643–G651. doi: 10.1152/ajpgi.00388.2014

Fig. 2.

Fig. 2.

Regulation of mitochondrial oxidation by determinants of pancreatitis. Pancreatitis can be induced by mitochondrial DNA mutations, nucleoside reverse transcriptase inhibitors (NRTIs), and valproic acid, all of which suppress mitochondrial oxidation. Major effectors of pancreatitis severity, caspase 1, NOD1, and TLR4, suppress mitochondrial oxidation. Mitochondrial oxidation promotes an anti-inflammatory macrophage phenotype and suppression of caspase 1 and TLR4 proinflammatory macrophage phenotype signals. mtDNA, mitochondrial DNA.