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. 2015 Feb 26;308(8):G702–G709. doi: 10.1152/ajpgi.00257.2014

Fig. 3.

Fig. 3.

SDF-1/CXCR4 signaling limits hepatocyte proliferation after hepatic I/R injury. Hepatocyte proliferation after I/R was determined by quantitative analysis of immunohistochemical staining for proliferating cell nuclear antigen (PCNA) in mice treated with PBS (vehicle), AMD3100, or recombinant murine SDF-1. Treatment with SDF-1 reduced hepatocyte proliferation, while treatment with the CXCR4 antagonist AMD3100 increased hepatocyte proliferation. Values are means ± SE; n = 6–8 per group. *P < 0.05 vs. control (vehicle).