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SDF-1/CXCR4 signaling does not regulate hepatic regeneration after partial hepatectomy. Mice were subjected to partial hepatectomy and injected intraperitoneally with PBS (vehicle), AMD3100 (10 mg/kg), or recombinant SDF-1 (1 μg) every 12 h starting 24 h after partial hepatectomy. Recovery of functional liver mass (A) and hepatocyte proliferation (B) was similar in all treatment groups at 48 h posthepatectomy. Values are means ± SE; n = 5 per group.
