Fig. 5.

Dihydrotestosterone (DHT) increased MAP in wild-type (WT) but not MC4R^−/− rats. WT and MC4R^−/− rats were treated with DHT, as described in methods, beginning at 5–6 wk of age. Controls received placebo pellets. At 14 wk of age, rats were implanted with radiotelemeters. After 2 wk, MAP was measured continuously for 8 days, and the data were averaged. A: body weights. B: MAP averaged over 8 days. *P < 0.05 compared with WT control; §P < 0.05 compared with DHT-treated WT; ¶P < 0.05 compared with untreated MC4R^−/−.