Table 1.
Arterial PaO2, Pco2, pH, and mean arterial pressure at baseline and 60 min following treatment in all rat groups
| Treatment Group | Time | PaCO2, mmHg | PaO2, mmHg | pH | MAP |
|---|---|---|---|---|---|
| Series 1: Intermittent Neural Apnea Is Sufficient for iPMF | |||||
| Brief Intermittent (n = 9) | baseline | 49 ± 1 | 282 ± 5 | 7.34 ± 0.01 | 127 ± 6 |
| 60 min | 49 ± 1 | 267 ± 7* | 7.33 ± 0.01 | 98 ± 7* | |
| Brief Massed (n = 9) | baseline | 48 ± 1 | 291 ± 5 | 7.35 ± 0.01 | 114 ± 7 |
| 60 min | 48 ± 1 | 286 ± 6 | 7.35 ± 0.01 | 108 ± 3 | |
| Prolonged (n = 9) | baseline | 47 ± 2 | 281 ± 3 | 7.36 ± 0.01 | 111 ± 5 |
| 60 min | 47 ± 1 | 269 ± 7 | 7.35 ± 0.01 | 98 ± 2 | |
| Time Control (n = 5) | baseline | 47 ± 1 | 292 ± 10 | 7.36 ± 0.01 | 111 ± 9 |
| 60 min | 47 ± 1 | 264 ± 11* | 7.36 ± 0.01 | 93 ± 11* | |
| Series 2: Spinal TNF-α Is not Necessary | |||||
| sTNFR1 + Brief Intermittent (n = 6) | baseline | 46 ± 1 | 292 ± 4 | 7.37 ± 0.01 | 108 ± 4 |
| 60 min | 46 ± 1 | 285 ± 7 | 7.35 ± 0.01 | 92 ± 8* | |
| aCSF + Brief Intermittent (n = 6) | baseline | 46 ± 1 | 274 ± 5 | 7.37 ± 0.01 | 93 ± 3 |
| 60 min | 46 ± 1 | 262 ± 7 | 7.36 ± 0.02 | 85 ± 6 | |
| sTNFR1 + Time Control (n = 3) | baseline | 45 ± 2 | 286 ± 3 | 7.36 ± 0.02 | 91 ± 6 |
| 60 min | 45 ± 2 | 271 ± 5 | 7.38 ± 0.00 | 99 ± 4 | |
| Series 3: Spinal aPKC Is Necessary | |||||
| Brief Intermittent + PKCζ-PS (n = 6) | baseline | 45 ± 1 | 267 ± 3 | 7.35 ± 0.01 | 110 ± 8 |
| 60 min | 45 ± 1 | 251 ± 4* | 7.37 ± 0.01 | 86 ± 11* | |
| Brief Intermittent + scrPKCζ-PS (n = 5) | baseline | 47 ± 1 | 273 ± 6 | 7.35 ± 0.02 | 121 ± 13 |
| 60 min | 47 ± 1 | 250 ± 4* | 7.32 ± 0.02 | 104 ± 11 | |
| Time Control + PKCζ-PS (n = 4) | baseline | 48 ± 0 | 285 ± 8 | 7.35 ± 0.01 | 124 ± 4 |
| 60 min | 48 ± 1 | 267 ± 18 | 7.36 ± 0.00 | 97 ± 8* | |
Data are presented as means ± SE. MAP, mean arterial pressure.
*
Significantly different than baseline, P < 0.05. No significant differences in any variable were detected at any time point between groups.