Fig. 3.

Effect of postnatally administered RGZ on perinatal nicotine exposure-induced alterations in mesenchymal markers of airway contractility in rat lung. Compared with the control group, with nicotine administration, the protein levels of fibronectin, α-smooth muscle actin (α-SMA), calponin, and collagens I or III increased significantly, and this effect was reversed in the RGZ-treated group. Top: representative Western blots for the markers and GAPDH. Bottom: densitometric values of the markers normalized to GAPDH. Values are means ± SE; n = 4 for each group. **P < 0.01 vs. control; #P < 0.05, ##P < 0.01 vs. nicotine.