Fig. 5.

Effect of RGZ on perinatal nicotine exposure-induced alterations in nicotinic acetylcholine receptors-α3 and -α7 (AChRα3 and AChRα7) in rat lung (A) and trachea (B). Compared with the control group, with nicotine administration, the levels of both receptors in the lungs and tracheas of the nicotine-treated animals increased significantly, and this effect was reversed in the RGZ-treated group. Representative Western blots for the receptors and GAPDH and density histograms are shown. Values are means ± SE; n = 4 for each group. *P < 0.05, **P < 0.01 vs. control; #P < 0.05, ##P < 0.01 vs. nicotine.