Table 2.
Susceptibility and FIC values of two clinical cystic fibrosis isolates of P. aeruginosa isolates tested with manuka honey and either tobramycin or colistin
Antibiotic | Pseudomonas aeruginosa reference number | Test method | MIC (µg/ml) antibiotic | FIC antibiotic | |
---|---|---|---|---|---|
Alone | With MH | ||||
Colistin | 867 | Broth dilution | 0.5 | 0.25 | 0.5 |
E strip | 0.38 | 0.19 | 0.5 | ||
Tobramycin | 867 | Broth dilution | 128 | 128 | 1 |
E strip | 32 | 32 | 1 | ||
Colistin | 1099 | Broth dilution | 16 | 4 | 0.25 |
E strip | 0.19 | 0.125 | 0.66 | ||
Tobramycin | 1099 | Broth dilution | 16 | 0.5 | 0.03 |
E strip | 2 | 0.5 | 0.25 |
1 % (w/v) below MIC was used in synergy tests. The FIC values seen were consistent across the methods used
FIC values are in bold
MH manuka honey