Table 1.
Focal | Localized edema Lipid exudates Intraretinal hemorrhages Focal hyperfluorescence in late fluorescein angiography |
Clinically significant without foveal thickening (non-center-involving) (sight-threatening) | Edema within 500 μm around the foveola Exudates within 500 μm around the foveola accompanied by edema Edema ≥ 1 optic-disk diameter within one optic-disk diameter around the foveola |
Clinically significant with foveal thickening (center-involving) | Ill-defined edema, which may be cystoid Exudates Intraretinal hemorrhages Origin of leakage often not clearly identifiable by fluorescein angiography |
Tractional | Due to vitreous traction to the fovea Thickened posterior hyaloid membrane OCT visualizes vitreal traction |
Ischemic maculopathy (occlusion of the perifoveal capillaries) | Loss of vision without any clearly visible cause on fundoscopy Fluorescein angiography needed for diagnosis Difficult to diagnose by fundoscopy only Edema may be present or absent |
OCT: Optical coherence tomography.