Table 5.
Cox proportional-hazards model. Disease-free survival and death in paediatric patients with ALL who were younger than 16 years of age and who were treated at the paediatric haematology service of the specialist “La Raza” IMSS Medical Centre.
| Characteristic | DFS 3 years | DFS 5 years | Death 3 years | Death 5 years | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| RR | 95% CI | P | RR | 95% CI | P | RR | 95% CI | P | RR | 95% CI | P | |
| Sex | ||||||||||||
| Male | ||||||||||||
| Female | 1.202 | 0.839–1.721 | 0.316 | 1.137 | 0.811–1.595 | 0.457 | 1.307 | 0.861–1.984 | 0.208 | 1.413 | 0.956–2.088 | 0.082 |
| Age (years) | ||||||||||||
| <1 | 4.288 | 0.531–34.611 | 0.172 | 3.947 | 0.495–31.454 | 0.195 | 0.000 | 0.000 | 0.000 | 3.616 | 0.446–29.352 | 0.229 |
| 1–5 | 1 | 1 | 1 | 1 | ||||||||
| 5.1–9.99 | 1.504 | 0.942–2.403 | 0.087 | 1.384 | 0.891–2.148 | 0.148 | 1.556 | 0.887–2.728 | 0.123 | 4.573 | 0.940–2.633 | 0.085 |
| >10 | 1.464 | 0.958–2.239 | 0.078 | 1.358 | 0.912–2.021 | 0.132 | 1.699 | 1.036–2.787 | 0.036 | 1.561 | 0.982–2.479 | 0.060 |
| Leucocytes (1 × 109/L) | ||||||||||||
| <10 | ||||||||||||
| 10–20 | 1.302 | 0.792–2.140 | 0.297 | 1.489 | 0.942–2.354 | 0.089 | 1.437 | 0.821–2.516 | 0.205 | 1.495 | 0.876–2.550 | 0.140 |
| 20–50 | 1.193 | 0.655–2.175 | 0.564 | 1.253 | 0.712–2.205 | 0.435 | 1.286 | 0.650–2.545 | 0.470 | 1.322 | 0.688–2.541 | 0.402 |
| 50–100 | 1.133 | 0.520–2.470 | 0.753 | 1.167 | 0.556–2.449 | 0.683 | 0.990 | 0.390–2.510 | 0.982 | 1.374 | 0.620–3.044 | 0.434 |
| >100 | 1.842 | 1.033–3.285 | 0.038 | 2.025 | 1.172–3.496 | 0.011 | 1.604 | 0.833–3.088 | 0.158 | 1.860 | 1.011–3.422 | 0.046 |
| Phenotype | ||||||||||||
| B | ||||||||||||
| T | 1.676 | 0.893–3.145 | 0.108 | 1.479 | 0.794–2.754 | 0.218 | 2.071 | 1.054–4.070 | 0.035 | 1.930 | 1.017–3.664 | 0.044 |
| Risk | ||||||||||||
| Standard | ||||||||||||
| High | 0.765 | 0.481–1.216 | 0.258 | 0.753 | 0.485–1.169 | 0.206 | 0.823 | 0.487–1.388 | 0.464 | 0.830 | 0.503–1.371 | 0.467 |
DFS: disease-free survival; RR: relative risk; CI: confidence interval.