Table 2.

Characteristics of the participants of the DIAN study by CDR stage and carrier status.

Variables	Mutation carriers (MCs) (N = 183)	Noncarriers (NCs) (N = 117)	P value
CDR 0
Age (years)	35.1 ± 8.8	39.4 ± 10.2	0.002∗
Gender (M/F)	46/61	45/64	0.800∗∗
Education level (years)	14.2 ± 2.7	14.7 ± 2.7	0.092∗
CDR sum of boxes	0.03 ± 0.1	0.01 ± 0.08	0.186∗
Logical memory, delayed recall (percentile)	55.3 ± 33.2	62.2 ± 31.1	0.181∗
MMSE	29.0 ± 1.3	29.1 ± 1.3	0.488∗
GDS	1.6 ± 1.9	1.2 ± 1.5	0.129∗
SMCs (number)	13	10	0.478∗∗
CDR 0.5
Age (years)	42.6 ± 9.3	42.4 ± 12.4	0.774∗
Gender (M/F)	21/27	2/6	0.449∗∗∗
Education level (years)	13.4 ± 2.3	12.5 ± 3.4	0.50∗
CDR sum of boxes	1.5 ± 1.1	0.6 ± 0.4	0.007∗
Logical memory, delayed recall (percentile)	17.4 ± 27.6	44.8 ± 39.4	0.015∗
MMSE	26.6 ± 2.8	28.4 ± 1.6	0.09∗
GDS	3.7 ± 3.4	2.1 ± 2.5	0.198∗
SMCs (number)	32	5	1.000∗∗∗
CDR ≥ 1
Age (years)	48.4 ± 8.6	n.a.
Gender (M/F)	14/14	0
Education level (years)	12.8 ± 2.7	n.a.
CDR sum of boxes	7.9 ± 4.1	n.a.
Logical memory, delayed recall (percentile)	10.4 ± 27.1	n.a.
MMSE	15.6 ± 6.3	n.a.
GDS	4.1 ± 3.1	n.a.
SMCs (number)	27	0

^∗Mann-Whitney U test; ^∗∗Chi-square test; ^∗∗∗Fisher's exact test; CDR denotes Clinical Dementia Rating Scale; M denotes male and F denotes female; MMSE denotes Mini-Mental Status Examination; GDS denotes Geriatric Depression Scale; age, education levels, CDR sum of boxes, MMSE, logical memory, and GDS scores are displayed in mean and standard deviation.