Table 2.

Changes in body weight and glucose metabolic parameters before and after therapies.

	Liraglutide (n = 16)		P value	Intensive insulin (n = 15)		P value
	Baseline	4 weeks		Baseline	4 weeks
Body mass index	27.3 ± 2.7	26.1 ± 2.3	P < 0.001	25.8 ± 2.5	25.1 ± 2.6	P = 0.003
Absolute change	−1.3 ± 0.6			−1.0 ± 0.8
% change (%)	−4.3 ± 2.4			−3.2 ± 2.1
HbA1c (%)	8.7 ± 1.0	8.0 ± 0.8	P < 0.001	8.9 ± 0.9	7.7 ± 0.8	P < 0.001
Absolute change (%)	−0.6 ± 0.4‡			−1.2 ± 0.9‡
% change (%)	−7.0 ± 4.3‡			−12.8 ± 9.9‡
Fasting plasma glucose (mg/dL)	149.8 ± 33.3	138.0 ± 41.3	P = 0.38	152.3 ± 30.7	108.1 ± 17.9	P < 0.001
Absolute change	−11.8 ± 51.5‡			−47.4 ± 36.5‡
% change (%)	−3.4 ± 34.4‡			−28.2 ± 17.5‡
Fasting blood CPR (ng/mL)	2.4 ± 1.2	3.7 ± 1.3	P = 0.004	1.8 ± 0.7	1.4 ± 0.5	P = 0.004
Absolute change	1.3 ± 1.5†			−0.4 ± 0.4†
% change (%)	84.2 ± 92.6†			−17.2 ± 25.3†
C-peptide index	1.65 ± 0.74	2.84 ± 1.09	P < 0.001	1.26 ± 0.51	1.28 ± 0.42	P = 0.77
Absolute change	1.19 ± 1.01†			0.02 ± 0.27†
% change (%)	89.7 ± 65.1†			11.4 ± 34.5†
Postprandial plasma glucose (mg/dL)	242.4 ± 62.2	166.9 ± 47.0	P < 0.001	262.9 ± 67.8	134.7 ± 37.6	P < 0.001
Absolute change	−75.6 ± 58.6‡			−128.3 ± 59.6‡
% change (%)	−28.2 ± 19.6†			−47.0 ± 13.8†
Postprandial blood CPR (ng/mL)	5.04 ± 3.40	6.73 ± 2.03	P = 0.03	3.93 ± 2.09	3.90 ± 1.50	P = 0.95
Absolute change	1.45 ± 2.70			−0.27 ± 1.45
% change (%)	62.2 ± 80.3‡			9.9 ± 37.4‡
GIR (mg/kg/min)	5.51 ± 2.33	7.64 ± 1.81‡	P < 0.001	5.46 ± 2.21	5.86 ± 2.51‡	P = 0.27
Absolute change	2.13 ± 1.77†			0.40 ± 1.34†
% change (%)	63.3 ± 75.2‡			11.8 ± 31.5‡

HbA1c, hemoglobin A1c; CPR, C-peptide radioimmunoreactivity; ^† P < 0.01, and ^‡ P < 0.05 liraglutide-therapy versus intensive insulin-therapy.