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. Author manuscript; available in PMC: 2016 May 1.
Published in final edited form as: Pancreas. 2015 May;44(4):636–647. doi: 10.1097/MPA.0000000000000308

Figure 4. Metformin effects on modulation of protein expression of AMPKα, AMPKβ, NF-κB and STAT3 in pancreatic tumors.

Figure 4

(A) Protein expression of of AMPKα and AMPKβ. (B) Protein expression of of NFκB and STAT3. The upper panel shows representative results of Western blot, and the lower panel shows densitometry analyses of the relative protein expression. Values are expressed as fold of the saline-treated control and are means ± SEM, n = 4. Metformin treatment significantly induced the phosphorylation of AMPKα, and AMPKβ1. Phospho-NFκB and phospho-STAT3 significantly decreased in Met_1wk, but not in Met_3wk, compared to the saline-treated control. *P < 0.05, **P < 0.01.