Table 1.
Characteristics of experimental groups of mice at time of sacrifice.
| Controls (n = 9 ) | Met_1wk (n = 10) | Met_3wk (n = 9) | P valuea | |
|---|---|---|---|---|
| Pancreatic tumor volume (mm3) | ||||
| Median (IQRe) | 481.1 (442, 551) | 181.8 (120, 256) | 137.9 (100, 202) | 0.0006 |
| P value | 0.0011b | 0.0009b, 0.5136c | ||
| Pancreatic tumor weight (mg) | ||||
| Median (IQR) | 551.1 (428, 578) | 248.4 (178, 316) | 266.7 (201, 285) | 0.0039 |
| P value | 0.0033b | 0.0054b, 0.6831c | ||
| Pancreatic tumor burdend (%) | ||||
| Median (IQR) | 1.97 (1.42, 2.44) | 1.00 (0.68,1.18) | 1.00 (0.79, 1.09) | 0.0076 |
| P value | 0.0055b | 0.0092b, 0.8703c | ||
| Body weight change (g) | ||||
| Median (IQR) | 4.5 (1.3, 5.3) | 4.3 (2.5, 5.8) | 3.8 (2.4, 5.0) | 0.6744 |
| P value | 0.4375b | 1.00b, 0.4622c | ||
| Blood glucose change (mg/L) | ||||
| Median (IQR) | −54.0 (−73, −33) | −51.5 (−68, −27) | −73.0 (−99, −59) | 0.1200 |
| P value | 0.5676b | 0.0932b, 0.0724c |
a
Kruskal-Wallis test for all groups,
b
Wilcoxon rank-sum test for Met-1wk vs. Controls or Met-3wk vs. controls
c
Wilcoxon rank-sum test for Met-3wk vs. Met-1wk
d
Tumor burden was calculated as tumor weight (mg) / body weight (mg) × 100
e
IQR – Interquartile Range (25th %, 75th %)