Table 1.
Alteration | Cancer type | References |
---|---|---|
Overexpression | Prostate, breast, bladder, ovarian, renal carcinoma, lung, liver, brain, gastric, esophageal, pancreatic, melanoma | [35,38,39-56,166] |
Activating mutations | Large follicular and B-cell lymphomas | [99,100,102,103] |
Inactivating/hypomorphic mutations | Myeloproliferative neoplasms Pediatric cancers | [115,116,118-120] |
H3.3K27M-mediated EZH2 inhibition | Pediatric gliomas | [121-124] |