Table 1.

EZH2 alterations and cancers

Alteration	Cancer type	References
Overexpression	Prostate, breast, bladder, ovarian, renal carcinoma, lung, liver, brain, gastric, esophageal, pancreatic, melanoma	[35,38,39-56,166]
Activating mutations	Large follicular and B-cell lymphomas	[99,100,102,103]
Inactivating/hypomorphic mutations	Myeloproliferative neoplasms Pediatric cancers	[115,116,118-120]
H3.3K27M-mediated EZH2 inhibition	Pediatric gliomas	[121-124]