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PO inhibited APAP induced IL-6 and TNFα expression in serum and liver of APAP-treated mice. PBS and PO pretreated mice were challenged with APAP for 6 h, then mice plasma were taken. The levels of TNFα (A) and IL-6 (B) were detected and the liver TNFα (C) and Ilα (D) mRNA level were measured by real-time PCR (n=4~5, *P < 0.05 versus PBS+APAP group).
