Table 2.

Estimated pharmacokinetic parameters of cisplatin in rat plasma after cisplatin administration (5 mg/kg, i.v.) after pelvic irradiation with and without 0.5 and 2 Gy irradiation

A. Pharmacokinetic parameters of cisplatin (CDDP) (5 mg/kg, i.v.) in ratplasma after pelvic irradiation with and without 0.5 and 2 Gy irradiation
Parameters	Control	Whole pelvic RT	Whole pelvic RT
	0 Gy	0.5 Gy	2 Gy
AUC (min μg/ml )	438 ± 27.5	789 ± 31.3*	819 ± 36.4*
t1/2 (min)	103 ± 25.0	182 ± 33.5*	173 ± 20.2*
Cmax (μg/ml)	8.78 ± 0.32	11.9 ± 0.43*	11.6 ± 0.89*
CL (ml/kg/min)	11.6 ± 0.68	6.39 ± 0.19*	6.19 ± 0.30*
MRT (min)	102 ± 16.5	205 ± 28.4*	193 ± 11.0*
B. Pharmacokinetic parameters of cisplatin (CDDP) (5 mg/kg, i.v.) in rat bile after pelvic irradiation with and without 0.5 and 2 Gy
Parameters	Control	Whole pelvic RT	Whole pelvic RT
	0 Gy	0.5 Gy	2 Gy
AUC (min μg/ml )	141 ± 11.9	123 ± 12.5	122 ± 10.5
t1/2 (min)	42.7 ± 4.7	33.6 ± 5.77	34.2 ± 3.77
Cmax (μg/ml)	4.01 ± 0.25	4.43 ± 0.58	4.53 ± 0.77
CL (ml/kg/min)	36.2 ± 4.67	41.0 ± 4.16	41.4 ± 3.17
MRT (min)	43.5 ± 3.9	38.2 ± 4.18	36.0 ± 4.05

Data expressed as mean ± standard error of the mean (n = 6). t_1/2: half-life; C_max: the maximum plasma concentration; AUC: area under the concentration-time curve; CL: total plasma clearance; MRT: mean residence time.

^* p < 0.05: significantly different from the control group.