Table 3.
Estimated pharmacokinetic parameters of cisplatin in rat plasma and lymphatic fluid after cisplatin administration (10 mg/kg, i.v.)
| Parameters | Plasma | Lymphatic fluid | ||
|---|---|---|---|---|
|
|
||||
| Without RT | With RT 2Gy | Without RT | With RT 2Gy | |
| AUC (min µg/mL) | 621 ± 47.7 | 956 ± 125* | 1718 ± 201 | 3214 ± 424* |
| T (min) | 140 ± 28.3 | 131 ± 16.1 | 71.2 ± 15.4 | 93.7 ± 14.1 |
| Cmax (µg/mL) | 15.3 ± 0.62 | 22.3 ± 0.84* | 17.1 ± 1.64 | 30.4 ± 4.05* |
| CL (mL/min/kg) | 13.7 ± 1.79 | 9.31 ± 1.40 | 6.09 ± 0.79 | 3.24 ± 0.40* |
| MRT (min) | 55.8 ± 2.23 | 59.4 ± 6.03 | 32.4 ± 2.9 | 30.2 ± 4.97 |
| Vss (mL/kg) | 1701 ± 162 | 1113 ± 126* | 272 ± 56.4 | 138 ± 23.3 |
Data expressed as mean ± SEM (n = 6). AUC, area under the concentration vs. time curve; t1/2, elimination half-life; Cmax, the peak plasma concentration of a drug after administration; CL, total body clearance; MRT, mean residence time; Vss, volume of distribution.
*
significantly different from without RT group at p < 0.05.