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(a and b) Shows the safe technique of intravitreal chemotherapy delivery. Site of injection selected is pars-plana. Cryotherapy is applied simultaneously at the injection site on withdrawal of 32-gauge needle (c and d) fundus photograph of right eye regressed retinoblastoma with persistent vitreous seeds inferotemporally after primary treatment. The vitreous seeds appear completely regressed after 6 cycles of intravitreal melphalan with no recurrence at 9 months follow-up
