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. 2015 Mar 14;13:88. doi: 10.1186/s12967-015-0447-7

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© Sun et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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HIF2α facilitated cardiac differentiation of ESCs. (A) The percentages of beating EBs derived from PB and PB-HIF2α mouse ESCs. Data represent the mean ± s.d. of three biological replicates. **p < 0.01 vs PB. (B) qRT-PCR analysis of Gata4, Tbx3, Mesp1, Nkx2.5 and Mef2c in PB and PB-HIF2α EBs at day 9. Data represent the mean ± s.d. of three biological replicates. *p < 0.05, **p < 0.01 vs PB. (C) qRT-PCR analysis of α-MHC and cTnT in PB- and PB-HIF2α EBs at day 15. Data represent the mean ± s.d. of three biological replicates. *p < 0.05, **p < 0.01 vs PB. (D) The differentiated cardiomyocytes from PB- and PB-HIF2α mouse ESCs were analyzed by FACS with cTnT and α-SMA staining.