Table 1.
Detail of group administration
| Group name | Compositions and ratio of drug | Dose (g/kg) |
|---|---|---|
| Normal (N) | Normal saline | Normalized |
| ANIT model (M) | Normal saline | Normalized |
| ANIT + A-dose (A) | Chi Shao:Dan Shen:Gua Lou: Ge Gen = 37.5:7.5:7.5:7.5 | 5.4 |
| ANIT + B-dose (B) | Chi Shao:Dan Shen:Gua Lou: Ge Gen = 75:15:15:15 | 10.8 |
| ANIT + C-dose (C) | Chi Shao:Dan Shen:Gua Lou: Ge Gen = 150:30:30:30 | 21.6 |
| ANIT + D-dose (D) | Chi Shao:Dan Shen:Gua Lou: Ge Gen = 300:60:60:60 | 43.2 |
| ANIT + E-dose (E) | Chi Shao:Dan Shen:Gua Lou: Ge Gen = 600:120: 120: 120 | 86.4 (MTD) |
| ANIT + F-dose (F) | Chi Shao:Dan Shen:Gua Lou: Ge Gen = 300:30:30:30 | 35.1 |
| ANIT + G-dose (G) | Chi Shao:Dan Shen:Gua Lou: Ge Gen = 600:30:30:30 | 62.1 |
There were the same contents of Chi Shao between D and F group, E and G group in CDTHD. However, the difference between the groups above was the ratio of Dan Shen, Gua Lou and Ge Gen versus Chi Shao.