Table 4.
Effect of CDTHD on histopathological changes in rat liver obtained at 48 h after ANIT administration (n = 10)
| Group | Hepatocyte hydropic degeneration | Hepatocellular necrosis | Sinusoid enlargement | Inflammatory cells infiltration |
|---|---|---|---|---|
| N | - | - | - | - |
| M | ++ | +++ | + | ++ |
| A | ++ | + | + | + |
| B | ++ | + | - | - |
| C | - | + | - | - |
| D | - | - | - | - |
| E | - | - | - | - |
| F | - | - | - | + |
| G | - | - | - | - |
Data were expressed as the mean of ten specimens for each group. + Mild, ++ Moderate, +++ Marked, − Negative. N: Normal, M: Model, A: 5.4 g/kg CDTHD, B: 10.8 g/kg CDTHD, C: 21.6 g/kg CDTHD, D: 43.2 g/kg CDTHD, E: 86.4 g/kg CDTHD, F: 35.1 g/kg CDTHD, G: 62.1 g/kg CDTHD.