Figure 2.

Altered p57 and Ki67 expression in embryonic pituitaries from mice with pituitary hypoplasia. Mouse embryonic pituitaries collected at E11.5 from normal and mutant Pitx2, Lhx3, and Lhx4 mouse embryos were fixed, embedded, sectioned in the midsagittal plane, and immunostained for p57 and the proliferation marker Ki67. The white arrow marks an abnormal invagination at the side of Rathke's pouch. White brackets show the extent of the representative immunostaining. Scale bar, 100 μm. Embryos are facing to the right.