Table 2.

Effects of Sleep Restriction on Hepatic Insulin Sensitivity

	Normal Sleep	Sleep Restriction	Pa
EGP, mg/kg · min
Fasting	2.59 ± 0.16	2.46 ± 0.13	.680
Hyperinsulinemic clamp	0.30 ± 0.03	0.19 ± 0.03	.040
Suppression, %	88 ± 2	92 ± 2	.053
GNG, % EGP
Fasting	26 ± 1.9	29 ± 1.8	.030
Hyperinsulinemic clamp	3.9 ± 0.06	4.6 ± 0.06	.006
Glycogenolysis, % EGP
Fasting	74 ± 1.9	71 ± 1.8	.039
Hyperinsulinemic clamp	96 ± 0.6	95 ± 0.6	.007

Abbreviations: EGP, endogenous glucose production; GNG, gluconeogenesis. n = 11. Data are means ± SEM.

^aP values were calculated by the Wilcoxon signed rank test; values in bold indicate statistical significance (ie, <.05).