Figure 2.

The identified mutations throughout MEN1. Although five mutations were found at high allele frequencies and thus are high-confident calls, extra four mutations were found to have low allele frequencies between 1 and 2% (Supplemental Table 4). *, This mutation has previously been described in patients diagnosed with MEN1 disorder (6). It has also been detected in three large intestine carcinoma specimens and one liver carcinoma (COSM1355794). **, This mutation has previously been found in sporadic parathyroid adenomas (9) (COSM255131).