Table 4.
Expert panel evaluation of epidemiological evidence | Low | |||||
Expert panel evaluation of toxicological evidence | Strong | |||||
Probability of causation, % | 40–69 | |||||
Percentile of exposure | 0–9 | 10–24 | 25–49 | 50–74 | 75–89 | >90 |
Percentile assumed | 0 | 10 | 25 | 50 | 75 | 90 |
Urinary MBP, micromolar | <LOD | 0.040 | 0.067 | 0.110 | 0.186 | 0.306 |
Urinary DEHP metabolites, micromolar | <LOD | 0.025 | 0.042 | 0.076 | 0.136 | 0.238 |
MBP-related change in T (assuming 10th percentile reference level), % | 0.00 | 0.00 | −4.07 | −4.07 | −4.07 | −4.07 |
DEHP related changes in T (assuming 10th percentile reference level), % | 0.00 | 0.00 | −2.04 | −6.22 | −13.46 | −25.77 |
Change in mean T, nmol/L | 0.00 | 0.00 | −1.01 | −1.70 | −2.89 | −4.92 |
Mortality RR (assuming 1.35 RR per 5.10 nmol/L increment in T) | 1 | 1 | 1.06 | 1.10 | 1.19 | 1.34 |
Deaths of 55− to 64-y-old men (baseline), n | 241 187 | |||||
Incremental deaths resulting from phthalate-attributable T, n | 24 820 | |||||
Lost economic productivity | €7.96 billion |
Abbreviation: LOD, limit of detection.