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Study design. Subjects received 72-hour infusions of RM-493 or placebo and then immediately were crossed over to the other treatment. In each period, after 48 hours of treatment, subjects entered the metabolic chamber at 8:00 am. REEC was measured at 9:30 to 10:00 and 10:30 to 11:00 am, meals were at noon (40% of kcal), 6:30 pm (50% of kcal), and 9:00 pm (10% of kcal), exercise was at 5:00 to 5:30 pm, and REEH was measured after subjects left the chamber.
