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Effect of RM-493 vs placebo on REEC at the end of the treatment period. REEC was measured on the third treatment day of each treatment arm in the metabolic chamber at thermoneutrality with subjects in the resting, postabsorptive state as the mean of 2 30-minute rest periods. Individual data points and aggregate data with error bars are the overall mean ± 95% CI. P values indicate significance of treatment differences using a paired t test.
