Table 3.

Metabolic Parameters and Hormone Levels After Placebo and RM-493 Administration in Obese Individuals

	RM-493	Placebo	P
Metabolic parameters
Fasting glucose, mg/dL	95 ± 5.8	91 ± 3.6	.003
Fasting insulin, μU/mL	26.2 ± 16	18.4 ± 12	.008
Fasting C-peptide, ng/mL	3.6 ± 1.2	3.2 ± 1.2	.043
Triglycerides, mg/dL	150 ± 70	129 ± 54	.035
FFA, mEq/L	0.442 ± 0.1	0.334 ± 0.1	.009
Total GLP-1, pmol/L	3.24 ± 1.15	2.27 ± 0.96	.003
Total PYY, pg/mL	53.0 ± 19.1	38.7 ± 16.6	.037
Thyroid parameters
TSH, μU/mL	1.86 ± 1.0	1.51 ± 0.73	.009
T3, ng/dL	119 ± 40	112 ± 36	.324
T4, μg/dL	8.9 ± 1.3	8.7 ± 1.7	.382
Free T3, pg/mL	2.6 ± 0.8	2.5 ± 0.7	.312
Free T4, ng/dL	2.2 ± 0.4	2.1 ± 0.3	.308

Posttreatment values shown are unadjusted means ± SD. P values indicate significance for comparisons between RM-493 and placebo.