Skip to main content
. 2015 Jan 16;156(4):1552–1564. doi: 10.1210/en.2014-1830

Figure 1. X-ray film autoradiograms of isotopic in situ hybridizations for rat and mouse OATP1c1, and mouse MCT8.

Figure 1.

A, OATP1c1 mRNA expression in the rat forebrain in the function of time following LPS injection. Hybridization signal decreases after LPS injection; at 4 and 9 h, the remaining visible signal in the hypothalamic paraventricular and supraoptic nuclei is vascular, whereas in other regions, such as the hippocampus and cortex, is primarily astrocytic. B, LPS has the same effect on OATP1c1 mRNA in mice as in rats. In mice, OATP1c1 mRNA decreases even in the choroid plexus at 9 h. C, MCT8 mRNA in the mouse brain following LPS administration. Neuronal labeling remains unchanged. The bottom panel shows magnified views of the diencephalic area, where several blood vessels (arrowheads) are labeled at 24 and 48 h, but none at 9 h after LPS. cp, choroid plexus; Hip, hippocampus; PVH, hypothalamic paraventricular nucleus; SO, supraoptic nucleus; tan, tanycytes; VMH, hypothalamic ventromedial nucleus. Scale bars = 2 mm.