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. 2015 Jan 21;156(4):1283–1291. doi: 10.1210/en.2014-1909

Figure 4. Nedd4+/− male mice on HFD exhibit reduced fasting glucose and insulin levels.

Figure 4.

A and B, GTT was carried out in wild-type (WT) and Nedd4+/− (Het) mice on HFD. After an overnight fast, mice received ip glucose 1.5 g/kg body weight, and then blood glucose levels were measured at time 0, 30, 60, 90, 120, and 180 minutes relative to glucose injection. Glucose clearance ability was similar between genotypes in males (A) or females (B) (n = 6–7). C and D, ITT was carried out in WT and Het male (A) and female (B) mice (n = 5–7). After a 4-hour fast, mice received ip insulin 0.75 U/kg body weight, and then blood glucose levels were measured at time 0, 30, 60, and 90 minutes relative to insulin injection. E and F, Serum insulin levels at time 0, 30, and 60 minutes after glucose injection during GTT in males (E) and females (F) (n = 6). G and H, After an overnight fast, blood glucose levels in male (G) and female (H) mice (n = 10–13). Data represent mean ± SEM. *, P < .05; ***, P < .001.