Table 1.
Male Reproductive Phenotypes
| WT |
Tac2−/− |
|||
|---|---|---|---|---|
| Mean ± SE | N | Mean ± SE | N | |
| Body weight | 27.2 ± 1.2 | 16 | 25.2 ± 1.7 | 16 |
| Testicular weight (g) | 196.5 ± 9.0 | 16 | 218 ± 42 | 16 |
| Testicular weight (% of body weight) | 0.73 ± 0.03 | 16 | 1.01 ± 0.23 | 16 |
| PND63 anogenital distance (mm) | 16.62 ± 0.3 | 10 | 15.54 ± 0.3a | 10 |
| Day of preputial separation | 31.7 ± 0.3 | 11 | 32.7 ± 0.5 | 10 |
| LH (ng/mL) | 0.06 ± 0.01 | 10 | 0.16 ± 0.06 | 11 |
| FSH (ng/mL) | 32.66 ± 3.65 | 10 | 14.73 ± 2.68a | 12 |
| Testosterone (ng/dL) | 30.6 ± 10 | 8 | 39.3 ± 13 | 8 |
Testicular weights as well as serum LH, FSH, and testosterone values were assayed between PND56–PND90. LH values below assay detectability of 0.02 ng/mL were set at this value for analysis.
a
P < .05 by unpaired t test.