Table 2.
Female Reproductive Phenotypes
| WT |
Tac2−/− |
|||
|---|---|---|---|---|
| Mean ± SE | N | Mean ± SE | N | |
| Body weight (g) | 17.6 ± 0.5 | 12 | 20.6 ± 0.5a | 12 |
| Ovarian weight (mg) | 10.0 ± 1.8 | 5 | 5.3 ± 0.9a | 5 |
| Ovarian weight (% of body weight) | 0.03 ± 0.01 | 5 | 0.02 ± 0.00a | 5 |
| Uterine weight (mg) | 71.1 ± 9.5 | 8 | 50.8 ± 9.6 | 8 |
| Uterine weight (% of body weight) | 0.30 ± 0.04 | 8 | 0.23 ± 0.04 | 8 |
| Day of vaginal opening | 29.11 ± 0.63 | 9 | 32.33 ± 1.62 | 9 |
| Day of first E | 34.67 ± 1.24 | 9 | 40.55 ± 2.3a | 9 |
| LH (ng/mL) | 0.24 ± 0.10 | 5 | 0.40 ± 0.34 | 7 |
| FSH (ng/mL) | 6.50 ± 2.04 | 5 | 5.94 ± 0.81 | 7 |
LH values below assay detectability of 0.02 ng/mL were set at this value for analysis.
a
P < .05 by unpaired t test (body weight, ovarian weight) or log-rank survival curve analysis (day of first E).