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. 2015 Feb 3;156(4):1303–1315. doi: 10.1210/en.2014-1849

Figure 7. Effects of ICV minocycline on basal food intake and ghrelin-mediated orexigenic actions.

Figure 7.

A, Summary showing mean effects of acute ICV administration of saline (control), Minoc, ghrelin, or the combination of minocycline and ghrelin (n = 4 for each group). Food intake was measured 2 and 4 hours after acute administration. *, P< .05, **, P< .01 compared with respective time control groups (Bonferroni's post hoc test). B, Summary effects on food intake of an acute ICV administration of saline or ghrelin in rats that previously received ICV injections saline or ICV Minoc. Groups included (acute-chronic) saline-saline (n = 6), ghrelin-saline (n = 6), saline-Minoc (n = 4), and ghrelin-Minoc (n = 5). Food intake was measured 6 hours after acute saline/ghrelin infusions. Data are represented as mean ± SEM. *, P < .05 vs saline-saline group (Bonferroni's post hoc test).