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. 2015 Jan 16;156(4):1464–1476. doi: 10.1210/en.2014-1926

Figure 6. Expression of PIK3CA* does not affect resumption and progression of the meiotic division.

Figure 6.

A, Number of COCs recovered from Cre− and Cre+ at PD35. Cre+ ovary released a high number of COCs. B, Cumulus expansion test. COC data were shown before (left) and after (right) IVM, respectively. Both Cre− (top) and Cre+ (bottom) COCs demonstrated normal cumulus expansion. Scale bar, 50 μm. C, Mature oocytes with polar body exclusion. Polar bodies are indicated by arrows. Oocytes from PD35 Cre− and Cre+ ovaries resumed meiosis with IVM. Scale bar, 50 μm. D, Meiotic stage distribution of oocytes after IVM. GV, arrested stage; GVBD, meiotic division has progressed to GVBD, which is the intermediate stage between GV and MII; Deg, degenerated. There were no significant differences between the 2 groups in the stage distribution of oocytes after IVM.