Table 2.
Significantly enriched biological processes affected by cisplatin
| Pathway | P-value | Modulated genes in the treated cells | Total genes in the pathway |
|---|---|---|---|
| Expression | |||
| Cell cycle | 0.001083 | 85 | 1399 |
| Enzyme linked receptor protein signaling pathway | 0.002002 | 62 | 886 |
| Regulation of cell proliferation | 0.002877 | 75 | 1189 |
| Regulation of cell cycle | 0.007228 | 54 | 741 |
| Negative regulation of cell cycle | 0.02095 | 39 | 456 |
| Cell cycle process | 0.03652 | 67 | 1070 |
| Neurogenesis | 0.03869 | 70 | 1142 |
| Splicing | |||
| mRNA metabolic process | 3.89E-12 | 69 | 635 |
| RNA splicing | 2.102E-10 | 46 | 328 |
| mRNA processing | 5.512E-10 | 51 | 408 |
| RNA processing | 1.002E-09 | 67 | 671 |
| RNA splicing, via transesterification reactions | 7.631E-07 | 33 | 219 |
| Nuclear mRNA splicing, via spliceosome | 1.935E-05 | 32 | 213 |
| RNA splicing, via transesterification reactions with bulged adenosine as nucleophile | 1.935E-05 | 32 | 213 |
| Cell cycle | 0.01964 | 89 | 1455 |
Genes that were regulated by more than 2-fold (Expression) or transcripts alternatively spliced (Splicing) by cisplatin were analysed by the ToppFun Suite software. The identified biological processes are indicated.