Table 4.
KEGG pathway annotation of the targets of differentially expressed miRNAs identified in BxPC-3 cells treated with oridonin
| Pathway Id | Pathway description | a S gene number | b TS gene number | c B gene number | d TB gene number | P value |
|---|---|---|---|---|---|---|
| 4080 | Neuroactive ligand-receptor interaction | 176 | 2158 | 206 | 2734 | 0.00899472 |
| 5200 | Pathways in cancer | 174 | 2158 | 204 | 2734 | 0.010837484 |
| 4010 | MAPK signaling pathway | 138 | 2158 | 155 | 2734 | 0.000542141 |
| 4510 | Focal adhesion | 123 | 2158 | 141 | 2734 | 0.00651097 |
| 4020 | Calcium signaling pathway | 118 | 2158 | 132 | 2734 | 0.000957212 |
| 4144 | Endocytosis | 92 | 2158 | 104 | 2734 | 0.00754512 |
| 4514 | Cell adhesion molecules (CAMs) | 79 | 2158 | 91 | 2734 | 0.03558939 |
| 4142 | Lysosome | 73 | 2158 | 79 | 2734 | 0.000942336 |
| 4640 | Hematopoietic cell lineage | 70 | 2158 | 76 | 2734 | 0.001553248 |
| 4670 | Leukocyte transendothelial migration | 69 | 2158 | 78 | 2734 | 0.0203194 |
| 4722 | Neurotrophin signaling pathway | 67 | 2158 | 76 | 2734 | 0.026182028 |
| 4660 | T cell receptor signaling pathway | 65 | 2158 | 74 | 2734 | 0.033536383 |
| 5414 | Dilated cardiomyopathy | 63 | 2158 | 68 | 2734 | 0.001810577 |
| 5410 | Hypertrophic cardiomyopathy (HCM) | 62 | 2158 | 66 | 2734 | 0.000696228 |
| 4350 | TGF-beta signaling pathway | 56 | 2158 | 62 | 2734 | 0.013956825 |
| 4512 | ECM-receptor interaction | 56 | 2158 | 63 | 2734 | 0.029353732 |
| 4912 | GnRH signaling pathway | 55 | 2158 | 62 | 2734 | 0.033519609 |
| 5215 | Prostate cancer | 52 | 2158 | 56 | 2734 | 0.004141376 |
| 5412 | Arrhythmogenic right ventricular cardiomyopathy (ARVC) | 52 | 2158 | 56 | 2734 | 0.004141376 |
| 4730 | Long-term depression | 47 | 2158 | 51 | 2734 | 0.009668211 |
| 5212 | Pancreatic cancer | 45 | 2158 | 50 | 2734 | 0.031740035 |
| 4720 | Long-term potentiation | 44 | 2158 | 48 | 2734 | 0.015812816 |
| 4662 | B cell receptor signaling pathway | 43 | 2158 | 48 | 2734 | 0.042316964 |
| 5211 | Renal cell carcinoma | 41 | 2158 | 45 | 2734 | 0.025499631 |
| 5220 | Chronic myeloid leukemia | 41 | 2158 | 45 | 2734 | 0.025499631 |
| 4115 | p53 signaling pathway | 39 | 2158 | 43 | 2734 | 0.034764924 |
| 5014 | Amyotrophic lateral sclerosis (ALS) | 37 | 2158 | 38 | 2734 | 0.001316211 |
| 5213 | Endometrial cancer | 32 | 2158 | 34 | 2734 | 0.015598239 |
| 520 | Amino sugar and nucleotide sugar metabolism | 26 | 2158 | 28 | 2734 | 0.046209141 |
| 51 | Fructose and mannose metabolism | 22 | 2158 | 23 | 2734 | 0.030443267 |
| 4330 | Notch signaling pathway | 20 | 2158 | 20 | 2734 | 0.008648864 |
aThe number of significantly differentially expressed genes matching KEGG pathways.
bThe total number of significantly differentially expressed genes.
cThe number of genes matching KEGG pathways.
dThe total number of genes.