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. 2014 Aug 31;9(2):18–25.

Table 4. Systematic reviews of interventional studies aiming to reduce antibiotic use in primary care.

Studies Number of studies (N); study period Countries studied Intervention Outcome
Huang, 201354 N = 13; 1946-2013 Six countries from Europe and North America. None from Asia-Pacific region Point-of-care C-reactive protein testing Significantly reduced antibiotic prescribing at the index consultation for patients with RTIs
Spurling, 201355 N = 10; 1966-2013 Four countries contributed all studies. New Zealand is represented Delayed antibiotics Reduced antibiotic use but is perceived as less satisfactory than immediate prescription by patients
Huttner, 201056 N = 22; 1990-2007 16 countries, mostly from Europe and North America. Australia and New Zealand represented Multi-faceted intervention (targeting both consumers and healthcare providers, using a variety of mass media and other interventions (guidelines, seminars, and academic detailing) Costs of campaigns are high but probably contributed to more careful use of antibiotics in the outpatient settings
Vodicka, 201357 N = 17; 1966-2012 Six high-income countries, mostly from Europe and North America. Australia represented Multi-faceted intervention (combinations of patient education materials, group education, academic detailing, opinion leaders, prescribing feedback, computerised decision support system, reminders, websites Interventions that combined parent education with clinician behaviour change decreased antibiotic prescribing rates by between 6-21%
Ivanovska, 201358 N = 8; 1990-2009 Six high middle income countries. China and Malaysia are represented Combinations of consumer and provider education Greater impact on antibiotic prescribing was achieved by multifaceted interventions focusing on specific diseases
Andrews, 201259 N = 23; 1966-2011 Three countries contributed all studies (Israel, UK and USA) Verbal or written information given to parents or their children In order to be most effective, interventions to influence parental consulting and antibiotic use should: Engage children, occur before an illness episode, employ delayed prescribing, and provide guidance on specific symptoms