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. 2015 Apr 10;15:39. doi: 10.1186/s12935-015-0187-z

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© Wazir et al.; licensee BioMed Central. 2015

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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General scheme illustrating the internal, external and perforin/granzyme pathways within apoptosis, including the sub-programmes specific to anoikis and DAP3. AKT/PKB: protein kinase B, CARD: caspase activation and recruitment domain, DAP3: death-associated protein 3, DD: death domains, DED: death effector domains, DELE: death ligand signal enhancer, DR: death receptor, DISC: death inducing signalling complex, FADD: Fas Associated Death, FLICE: FADD-like interleukin-1 beta-converting enzyme, IPS: 1interferon-β promoter stimulator 1.