TABLE IV.
Predisposition to pancreatic ductal adenocarcinoma (pdac) in 211 enrolled familiesa with available family histories
| Classification | Families [n (%)] |
|---|---|
| Sporadic pdac | 152 (72.0) |
| Non-sporadic pdac | 59 (28.0) |
| Familial pdacb | 39 (18.5) |
| 2 Affected relatives | 34 (16.1) |
| 3 Affected relatives | 2 (0.9) |
| ≥4 Affected relatives | 3 (1.4) |
| Genetic syndrome diagnosis | 8 (3.8) |
| Hereditary breast and ovarian cancer (BRCA1) | 3 (1.4) |
| Hereditary breast and ovarian cancer (BRCA2) | 2 (0.9) |
| Hereditary breast and ovarian cancer–like (PALB2) | 1 (0.5) |
| Familial atypical multiple-mole melanoma (CDKN2A) | 1 (0.5) |
| Peutz-Jeghers syndrome (STK11) | 1 (0.5) |
| Young-onset pdac (≤50 years) | 12 (5.7) |
a
With 1 or more cases of pdac (n = 209) or otherwise at risk of pdac (n = 2).
b
Defined as 2 or more pdac-affected relatives in a family, without diagnosis of a known genetic syndrome.