TABLE III.

Treatment algorithm for acneiform rash

Mild (grade 1)	Maintain dose level of epidermal growth factor receptor (egfr) tyrosine kinase inhibitor (tki). Apply hydrocortisone valerate topically twice daily as needed.
Moderate (grade 2)	Maintain dose level of egfr tki. Oral minocycline 100 mg twice daily for 4 weeks AND hydrocortisone valerate topically twice daily as needed. For prolonged grade 2 rash, egfr tki can be temporarily discontinued until improvement to grade 1 or less. Reintroduce egfr tki at a dose of the physician’s discretion.
Severe (grade 3)	Temporary discontinuation of egfr tki for 2–4 weeks. Upon improvement to grade 2 or less, reintroduce egfr tki at a dose of the physician’s discretion. If toxicities do not worsen, escalate the dose. If no improvement, discontinue. Oral minocycline 100 mg twice daily for 4 weeks AND hydrocortisone valerate topically twice daily as needed.