Skip to main content
. 2015 Apr;22(2):123–132. doi: 10.3747/co.22.2430

TABLE V.

Treatment algorithm for stomatitis or mucositis

Mild (grade 1)

  • Maintain dose level of epidermal growth factor receptor (egfr) tyrosine kinase inhibitor (tki).

  • Apply triamcinolone in dental paste 2–3 times daily as needed.
Moderate (grade 2)

  • Maintain dose level of egfr tki.

  • Apply triamcinolone in dental paste 2–3 times daily as needed

    AND

    oral erythromycin 250–350 mg daily

    OR

    minocycline 50 mg daily.
Severe (grade 3)

  • Temporary discontinuation of egfr tki for 2–4 weeks. Upon improvement to grade 2 or less, reintroduce egfr tki at a dose of the physician’s discretion. If toxicities do not worsen, escalate the dose. If no improvement, discontinue.

  • Apply clobetasol ointment, 2–3 times daily as needed

    AND

    oral erythromycin 500 mg daily

    OR

    minocycline 100 mg daily.