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. Author manuscript; available in PMC: 2015 Apr 16.
Published in final edited form as: J Immunol. 2010 Sep 22;185(8):4896–4903. doi: 10.4049/jimmunol.1001857

FIGURE 2.

FIGURE 2

LPS-conditioned media disrupt saccular airway branching in TLR4 mutant explants. Media from control and LPS-treated BALB/cJ explants were added to LPS-resistant C.C3-Tlr4Lpsd/J explants. A–F, Brightfield images of C.C3-Tlr4Lpsd/J explants cultured with control-conditioned media (A, D), LPS-conditioned media (B, E), or LPS-conditioned media with the NF-κB inhibitor parthenolide (1 μM; C, F) (original magnification ×25). Higher-magnification images are shown in D–F (original magnification ×200). Arrows indicate saccular airways. G, LPS-conditioned media inhibited formation of new saccular airways in C.C3-Tlr4Lpsd/J explants. *p < 0.001; n = 7. H, LPS-conditioned media inhibited FGF-10 expression in C.C3-Tlr4Lpsd/J explants, as measured by real-time PCR. *p < 0.05; n = 9.