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GM3 synthase prevents caspase-3 activation. Western blot analysis of GM3 synthase expression in SKOV3/GS cells using V5 antibody. SKOV3 and SKOV3/GS cells were treated with 100 nM Taxol for 48 h and GM3 synthase was detected by Western blot analysis using V5 antibody as described in the Material and Methods. Note that forced expression of GM3 synthase attenuates Taxolinduced apoptosis (Figure 1(a)) and caspase-3 activation.
